Alternate-Day Statin Therapy
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چکیده
In a previous article, I discussed adverse drug reactions (ADRs) attributed to statin therapy, specifically myopathies, as well as potential consequences and recommended alternatives. These ADRs are not trivial because they may lead to patient harm in severe cases and/or significant patient nonadherence in most cases. In fact, statins are frequently discontinued as a result of ADRs1,2 and for an inability to pay,2 leaving many statin-eligible patients at increased risk for cardiovascular morbidity and mortality.
منابع مشابه
Alternate-day statin therapy for the treatment of hyperlipidemia.
OBJECTIVE To evaluate the safety, efficacy, and cost of alternate-day statin therapy in the treatment of hyperlipidemia. DATA SOURCES Systematic searches were conducted for primary literature sources involving alternative statin regimens using PubMed, EMBASE, Google Scholar, and International Pharmaceutical Abstracts (January 1966-March 2010). Articles selected were limited to those published...
متن کاملAlternate-Day Statin Therapy
In a previous article, I discussed adverse drug reactions (ADRs) attributed to statin therapy, specifically myopathies, as well as potential consequences and recommended alternatives. These ADRs are not trivial because they may lead to patient harm in severe cases and/or significant patient nonadherence in most cases. In fact, statins are frequently discontinued as a result of ADRs1,2 and for a...
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BACKGROUND Intensive statin therapy reduces major adverse cardiovascular events (MACE), but the effect on mortality is unclear. OBJECTIVE To determine whether intensive statin therapy reduces all-cause mortality compared with moderate statin therapy in patients with recent acute coronary syndromes (ACS) and stable coronary heart disease (CHD). METHODS Medline, Embase, the Cochrane Database,...
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The efficacy and safety of Salvia officinalis combined with statin have not been evaluated in dyslipidemic diabetes mellitus type 2 (DDMT2) so far. The plant extract antioxidant activity was determined by the DPPH radical scavenging assay. The total flavonoid, total phenolic and quercetin contents of the capsules containing the plant extract were also measured. Moreover, the effects of 2-month ...
متن کاملMonday, Wednesday, and Friday dosing of rosuvastatin in patients previously intolerant to statin therapy.
Statins are normally administered for the treatment of dyslipidemia on a daily basis. This standard dosing regimen is well tolerated by most patients. Occasionally, patients discontinue therapy secondary to side effects, most commonly myalgias. We describe 2 patients who were unable to tolerate daily atorvastatin therapy secondary to myalgias and were subsequently treated with rosuvastatin admi...
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